Intracin MICIX (Amikacin Injection BP 250 mg/ml) is a potent aminoglycoside antibiotic indicated for the treatment of serious gram-negative bacterial infections in various veterinary species.

INDICATIONS

• Serious Gram-Negative Infections: Systemic treatment of infections caused by susceptible organisms, particularly Pseudomonas spp., E. coli, and Proteus spp.
• Intrauterine Infusion in Mares: Specifically approved for treating uterine infections in horses.
• Serious Infections in Other Species: Used in other livestock and small animals to treat severe, documented bacterial infections when other less toxic antibiotics are ineffective.
• Clinical Settings with High Resistance: Used as a treatment of last resort when gentamicin-resistant bacteria are a clinical problem.

ADMINISTRATION

• Route: Typically given by injection for systemic infections or via intrauterine infusion in mares.
• Precautions: The drug must be used with extreme caution and monitoring in animals with pre-existing renal disease, dehydration, sepsis, or advanced age.
• Side Effects: Common risks include potential kidney damage (nephrotoxicity) and ear toxicity (ototoxicity).
• Dosing Guidelines: In systemic use, it often exhibits concentration-dependent bactericidal activity, sometimes administered as a large, once-daily dose to maximize killing rate.